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Models & Performance

  • Execute up to 15 models to generate outputs on up to 8 DACs; multiple models driving one DAC are automatically summed
  • Fast update rates: over 300 kHz with one Hodgkin/Huxley model and 270 kHz with two models (see table below)
  • Detection of overload in hardware gives confidence in your results
  • Ergonomic dialogs make it easy to view and edit the model parameters
  • Modify model parameters and apply your changes while sampling
  • Switch automatically between multiple parameter states during sampling
  • Pulse and waveform outputs defined by the user can be summed into the outputs generated by dynamic clamping
  • Output sequencer can enable and disable individual models dynamically during a single sampling sweep


Update rates

H-H models x1 x2 x4 x8
Power1401-3
320kHz 270kHz 175kHz 105kHz
Power1401 mkII
100kHz 85kHz 60kHz 45kHz
Micro1401-4
345kHz 294kHz 233kHz 154kHz
Model class Type
Hodgkin-Huxley

Alpha/Beta*
Tau

Synapse

Alpha
Central pattern generator
Destexhe
Electrical
Exponential
Exponential difference
User defined*

Leak

Linear
GHK
Boltzmann
User defined*

Noise

Ornstein-Uhlenbeck
Scaled Ornstein-Uhlenbeck

* These models can be customised or extended by replacing numerical parameters with user generated tables of values.

During testing we have found that, with older amplifier designs, current clamp performance is not good enough for effective dynamic clamping.

So far the following amplifiers have been tested at CED and seen to work correctly with Signal dynamic clamping:

  • Molecular Devices Multiclamp 700A and 700B
  • NPI BA-03X
  • A-M Systems 2400
  • HEKA EPC 800

Other amplifiers will be tested and added to this list in due course.

However, many other amplifiers, including the BA-01X, BA-01M, ELC-01X, ELC01M, ELC03XS, SEC03M, SEC05X and SEC01X from NPI Electronics, are known to work well with current clamping and are therefore suitable for dynamic clamping, but of course this is not to say that other amplifiers are unsuitable. ×

Cambridge Electronic Design Limited

Registered in England: 00972132

Registered office:

  • Cambridge Electronic Design Limited,
  • Technical Centre,
  • 139 Cambridge Road,
  • Milton,
  • Cambridge CB24 6AZ
  • ENGLAND.

VAT: GB 214 2617 96

Producer registration number: WEE/BD0050TZ

Terms and Conditions of Sale

For our US customers, we can provide tax form W-8BEN, that identifies us as a UK company.

DUNS: 219151016
CAGE/NCAGE: KB797
NAICS: 423490
Commodity codes
Hardware: 84716070
Software: 85234945
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By email:

info@ced.co.uk

By post:
  • Cambridge Electronic Design Limited,
  • Technical Centre,
  • 139 Cambridge Road,
  • Milton,
  • Cambridge CB24 6AZ
  • ENGLAND.
By telephone:

(Int.+44) (0)1223 420186

From North America (Toll Free):

1 800 345 7794

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