Patch clamp

Signal incorporates many powerful features for whole cell and single channel experiments that make it ideal for electrophysiological recording. Familiar terms, and easily set up protocols for standard requirements enable the user to get started quickly using Signal and a CED 1401 data acquisition interface. Signal also incorporates an import function allowing you to analyse data from other recording systems.

Clamp specific sampling support

• Nominate a particular recording state to be used for seal and membrane resistance measurements.
• Easy adjustment of holding potentials.
• Dynamic readout of seal resistance.
• Support for dynamic clamp studies with up to 15 selectable conductance models. Update rates of over 300kHz without timing jitter - see details.

• Membrane analysis option displays measurements of total resistance, access and membrane conductance, capacitive transient decay time constant and membrane capacitance.
• Display selected measurements as a graph against time.

Amplifier communication

• Telegraph communication to set channel scales based on voltages supplied from a wide range of patch clamp amplifiers.
• Direct software communication with Molecular Devices MultiClamp 700 and Axoclamp 900 amplifiers. Reads values for gains, filter settings, membrane capacitance, series resistance and external command sensitivity. The values read are stored in the Signal data file.