This online script controls a TMS machine to generate the pulses required to build up a plot of MEP amplitude vs. stimulus intensity.
Stimulus intensities are randomised to minimise habituation and can be applied singly, under manual control, or automatically at fixed intervals. MEP amplitudes are measured automatically within a user-defined time range. A best fit Bolzmann sigmoid curve fit updates after each stimulus. There are options to edit the Intensity-Response plot to exclude data points where the background noise level was too high. In addition, the plot can be normalised relative to user-defined upper and lower limits.
MEP recordings, I-R plot and a spreadsheet of results, including the sigmoid fit statistics are saved to disk. The degree of automation means that it should be possible to obtain high quality intensity –response plots in only a few minutes.
The script includes a .pdf user guide and a quick-reference version that displays while the script is running at the click on a toolbar button.
- Signal v7.07 or higher.
- ghutils.sgs, ghgridutils.sgs. Store these libraries of script functions in your SignalN folder (where N is the version number) in the folder named include. Alternatively, keep these files in the same folder as the FastMEPsr v10 script.
- A TMS machine and appropriate remote control cables. Supported TMS devices include: MagStim, MagPro, PowerMag, DuoMag, DS8R and Neurosoft models.