MT.zip

Traditionally the motor threshold has been defined as the stimulus intensity which generates a response above a pre-defined amplitude. Simply put, it involves increasing or decreasing the intensity until an average response of a particular pre-defined size is obtained on ~50% of stimuli. This is most often done at rest (resting motor threshold – RMT), but can also be done during weak muscle contraction (active motor threshold – AMT).

This configuration allows you to manually adjust the stimulus intensity of your TMS device, and will plot the amplitudes obtained.

SR.zip

This configuration is used to plot a range of stimulus intensities against the amplitude of the response to generate a stimulus response curve. Single TMS pulses are given at a set range of stimulus intensities, with the order of stimulus intensities randomised across trials.

SICI.zip

SICI involves alternating between a single “test” pulse to generate the baseline or test response, and closely-spaced pairs of pulses where the first pulse is used to condition the response to the test pulse (hence “conditioning” pulse).

This can be achieved by two methods; either the interval between the pulse pair is altered randomly across trials (interval SICI) or the interval between the pulse pair is fixed and the intensity of the conditioning pulse is altered instead (SICI input-output curve).

SICF.zip

SICF configurations alternate between a single “test” pulse to generate the baseline or test response, and closely-spaced pairs of pulses where the second pulse is used to “condition” the response to the test pulse, which now comes first. The design of this experiment is similar to SICI, except for the greater time resolution of the interval between pairs (0.2 to 0.3 ms steps) and with the test pulse set to a higher intensity than the second.

LICI.zip

LICI involves alternating between a single “test” pulse (to generate the baseline or test response) and pairs of pulses with a longer interval (up to 200 ms) between them, where the first pulse is used to “condition” the response to the test pulse. The design of this experiment is similar to SICI except that the interval between pairs is much longer (100-200 ms).

IHI.zip

IHI protocols require alternating between a single “test” pulse to generate the baseline or test response delivered through one coil, and pairs of pulses, one pulse delivered through the test coil and the other through a secondary coil. This experiment requires two independently triggered stimulators, and two stimulation coils will be required.