Data acquisition

  • Record and display fast sweeps of waveform data to disk with over 15 million data points per sweep with a Power1401

  • Output pulse, sine, ramp and stored waveforms while sampling
  • Generate sets of varying stimuli on up to 8 waveform and 16 digital outputs
  • Set up multiple output states, each providing differing pulse outputs or stimuli. Sequence the order and repeats of each state cyclically, randomly, semi-randomly, manually or to a predefined protocol. Frames are marked with the state used
  • Sample multiple waveform inputs at aggregate rates up to 1MHz
  • Easily switch sampling configurations or output protocols
  • Capture free-running or triggered sweeps with post or peri-trigger modes
  • Gap free option for acquisition of continuous data



  • Trigger data capture from external pulse, waveform threshold crossing or internal clock
  • Sample variable numbers of points in different sweeps
  • Tag frames to indicate state or artefacts for selective review and analysis
  • Perform built-in and custom analyses on incoming sampled data
  • Configure software controllable amplifiers including the CED1902 low noise isolated pre-amplifier, the Digitimer D360 and D440 isolated patient amplifiers and the Power1401 gain option
  • Automatically adjust channel scaling in response to gain changes detected from either patch clamp amplifier telegraphs or supported software controlled amplifiers
  • Simultaneously review earlier frames together with incoming data using duplicate windows
  • Sample at arbitrary or varying rates with external convert input option

Pulses configuration dialog

System requirements

For sampling, Signal version 6 requires a CED Micro1401, Power1401 or 1401plus intelligent laboratory interface and a PC with Windows XP SP3, Vista™, 7, 8 or 10, or Intel Macintosh running Windows. The computer must be modern enough to support the SSE2 instruction set. We recommend a minimum of 2GB of RAM. Signal dynamic clamping requires a CED Power1401-3 or Power1401 mk II intelligent laboratory interface.

Both 64-bit and 32-bit OS versions are supplied; either version can be used on systems running a 64-bit OS. See the compatibility table. When installed on a 64-bit system the 64-bit version provides a performance increase and access to more memory.

Test computer for SSE2 compatibility

The latest versions of Spike2 and Signal require the SSE2 instruction set extension to the IA32 (x86) instruction set. It started to be added to Intel 32-bit CPUs in 2000 and to AMD CPUs in 2003. All 64-bit capable CPUs support this. The following link has a little more information:

If you are unsure about your computer, to test it for compatibility, please download, extract SSE2check.exe and run it to get a direct answer. ×

Cambridge Electronic Design Limited

Registered in England: 972132

Registered office:

  • Cambridge Electronic Design Limited,
  • Technical Centre,
  • 139 Cambridge Road,
  • Milton,
  • Cambridge CB24 6AZ

VAT: GB 214 2617 96

Producer Registration number: WEE/BD0050TZ

Terms and Conditions of Sale

For our US customers, we can provide tax form W-8BEN, that identifies us as a UK company.

DUNS: 219151016
NAICS: 423490
Commodity codes
Hardware: 84716070
Software: 85234945

By email:

By post:
  • Cambridge Electronic Design Limited,
  • Technical Centre,
  • 139 Cambridge Road,
  • Milton,
  • Cambridge CB24 6AZ
By telephone:

(Int.+44) (0)1223 420186

From North America (Toll Free):

1 800 345 7794


Privacy policy

CED, through this site, does two things that relate to privacy. We would like to explain them.

Emails from down-loads

We offer free down-loads of many files on our site, from test programs to complete install files for updated versions of major packages like Spike2 and Signal.

When customers wish to take a down-load of a major package, we ask a few questions, including their name, email address, the serial number of the software for which they seek an upgrade and whether they would like an automatic email whenever we update the product. This information is emailed back to CED when they access the final down-load screen. Within this email, your browser transmits the type and version of browser you are using, and the screen resolution you are running.

The reasons why we take and keep this information are that it is useful for our software development team to know who has taken the latest versions, and it is useful for our web site development team to know which browsers people are using to view our site, and what resolution they have their screens set to.


When people down-load a major package, we try to write a cookie, a small file in your computer, that records your name, serial number of the software package, and the version you are down-loading. These files have a lifetime of one year.

The reasons for storing this information are firstly that if you ask for another down-load some other time, your details are read from the cookie and are pre-written into the form, to save you looking them up again. The other reason is that next time you access our site, your browser looks through your CED cookies and compares the versions down-loaded with the latest version numbers read from our site. If there is a later version of a product you have already down-loaded, we tell you on the home page screen, so you know that it is worth going to the down-load page again.

None of this information is ever given to anyone outside CED. ×