Advanced features

Multiple sampling conditions

Signal includes a comprehensive multiple output states system that provides differing pulse outputs or stimuli while sampling. The order and repeats of each stimulus can be sequenced using a predefined protocol or executed randomly, semi-randomly or under manual control. Each frame of data is marked to indicate the stimulus that was used.

Dynamic clamping

High speed, fully integrated functions to simulate ion channels and leaks and use simulated synapses to generate hybrid networks. Optimised look-up tables and fast arithmetic are utilised in the Power1401-3 or mk II interface for maximum output data rates. Up to 15 selectable models can be used and switched between while sampling.

Exponential difference synapse model with superimposed
noise, triggered internally at randomised intervals

Voltage and current clamp

Interactively control holding potentials and pulse outputs using the graphical sequencer. Construct I/V plots, leak subtraction and curve fits on-line and off-line.

Single channel patch clamp

Detect single and multi-level channel openings on-line and off-line automatically. Produce measurements such as open/closed times and amplitudes and display result histograms. A special feature is the reverse convolution fitting of an amplifier's step response (SCAN analysis) to filtered single channel patch clamp data allowing superior time resolution of events.

Click to play video

This video tutorial demonstrates how to analyse single
channel data using the threshold detection method

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Signal has a number of features for single channel patch clamp data analysis, including idealized trace formation using threshold detection, and generation of dwell time and amplitude histograms. This video tutorial demonstrates how to analyse single channel data using the threshold detection method.

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  • ENGLAND.
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